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Cell Signaling Sars-Cov-1/2 Nucleocapsid Protein (1c7c7) Mouse mAb
List Price
$354.51
Your Price
$354.51
Cell Signaling Sars-Cov-1/2 Nucleocapsid Protein (1c7c7) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-68344S
MFG.PART:
68344S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | Vir |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 55 |
| Source/Isotype | Mouse IgG2a |
| Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:200 - 1:800} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SARS-CoV-1/2 Nucleocapsid Protein (1C7C7) Mouse mAb recognizes endogenous levels of total nucleocapsid (N) protein from SARS-CoV-1 and SARS-CoV-2. |
| Species Reactivity | Virus |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to SARS-CoV-1 nucleocapsid (N) protein. |
| Background | The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), 9 accessory proteins, and 4 canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N) (2). The nucleocapsid (N) protein is a phosphoprotein that plays a critical role in viral assembly (3,4). It binds to the viral genomic RNA, enabling its packaging into the ribonucleoprotein complex (RNP), and is the most abundant protein in the virion (5). Evidence from studies in SARS-CoV-2 and other coronaviruses suggest functions for nucleocapsid (N) protein beyond viral RNA packaging, including roles in viral replication (6) and suppressing host immune responses to viral infection (7). |
| SKU | CSIG-68344S |
|---|---|
| Supplier Part Number | 68344S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |