Cell Signaling Mt-Atp6 Antibody

Name: Cell Signaling Mt-Atp6 Antibody
SKU: CSIG-70262S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Mt-Atp6 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-70262S

MFG.PART: 70262S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	20
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MT-ATP6 Antibody recognizes endogenous levels of total MT-ATP6 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP6 protein. Antibodies are purified by peptide affinity chromatography.
Background	Mitochondrially-encoded ATP Synthase Membrane Subunit 6 (MT-ATP6) is a product of MT-ATP6, one of 13 protein-encoding genes in the mitochondrial genome. MT-ATP6 comprises one subunit of the transmembrane F1FO ATP synthase (Complex V), which catalyzes the final step of oxidative phosphorylation in the electron transport chain (1). A number of mutations in the MT-ATP6 gene have been identified that lead to defects in oxidative phosphorylation. Many of these are strongly associated with distinct disease states, including Leigh syndrome (2) and Charcot-Marie-Tooth disease (3).

Specifications