Cell Signaling Tbk1/Nak (E8i3g) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Tbk1/Nak (E8i3g) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-71543SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Tbk1/Nak (E8i3g) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-71543SF

MFG.PART: 71543SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	84
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #38066
Specificity/Sensitivity	TBK1/NAK (E8I3G) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total TBK1/NAK protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TBK1/NAK protein.
Background	TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).

Specifications