Cell Signaling Cd235a/Glycophorin A (Jc159) Rabbit mAb

Name: Cell Signaling Cd235a/Glycophorin A (Jc159) Rabbit mAb
SKU: CSIG-75126S
Price: 352.49 USD

List Price $352.49 Your Price $352.49

Cell Signaling Cd235a/Glycophorin A (Jc159) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-75126S

MFG.PART: 75126S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:800 - 1:3200}
Storage	Supplied in a Tris-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD235a/Glycophorin A (JC159) Rabbit mAb recognizes endogenous levels of CD235a/Glycophorin A protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with membrane preparations from splenic hairy cell leukemia cells.
Background	CD235a/Glycophorin A, also known as GPA, is one of the major sialoglycoproteins expressed on human red blood cells, specifically in mature erythrocytes and erythroid precursor cells (1). The GPA gene is encoded for both M- and N-blood group antigens. CD235a/Glycophorin A is characterized as a class I transmembrane protein because it has a cleavable signal peptide and a single membrane-spanning domain (2). The CD235a/Glycophorin A protein is required for the high activity structure of AE1/SLC4A1 and plays an important role in the function of the anion exchange protein (3). CD235a/Glycophorin A is a receptor for Hepatitis A virus (HAV), influenza virus, and parvovirus (4-6).