Cell Signaling Cd21/Cr2 (2g9) Mouse mAb

Name: Cell Signaling Cd21/Cr2 (2g9) Mouse mAb
SKU: CSIG-76069S
Price: 385.82 USD

List Price $385.82 Your Price $385.82

Cell Signaling Cd21/Cr2 (2g9) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-76069S

MFG.PART: 76069S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2a
Application/Dilution	{IHC Leica Bond: 1:200 - 1:800, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD21/CR2 (2G9) Mouse mAb recognizes endogenous levels of CD21/CR2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to the external domain of human CD21/CR2 protein.
Background	Complement receptor type 2 (CD21/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9).

Specifications