Cell Signaling Ccl20 (E6j9k) Rabbit mAb

Name: Cell Signaling Ccl20 (E6j9k) Rabbit mAb
SKU: CSIG-76924S
Price: 374.71 USD

List Price $374.71 Your Price $374.71

Cell Signaling Ccl20 (E6j9k) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-76924S

MFG.PART: 76924S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	9
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CCL20 (E6J9K) Rabbit mAb recognizes endogenous levels of total CCL20 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human CCL20 protein.
Background	Chemokine (C-C motif) ligand 20 (CCL20), also known as macrophage inflammatory protein (MIP)-3α, liver activation regulated chemokine (LARC), and Exodus-1, is a chemokine that mediates leukocyte migration during inflammation and homeostasis (1-3). CCL20 is expressed by T helper (Th) 17 cells (Th17), B cells, natural killer cells, neutrophils, dendritic cells (DC), macrophages, and endothelial cells (4-6). Its receptor, C-C chemokine receptor 6 (CCR6), is expressed by immune cells, such as regulatory CD4+ T cells (Tregs), Th17 cells, CD8+ T cells, and B cells, and drives their migration into CCL20 rich tissues (7). In induced Tregs, CCL20 ligation with its receptor suppresses Treg function via signaling through the AKT/mTOR/STAT3 axis (8). The CCR6-CCL20 axis is being investigated as a therapeutic target for its role in autoimmune disease, viral infection, and cancer progression (7,9).

Specifications