We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cell Signaling Akap11 (E9e6w) Rabbit mAb
List Price $354.51 Your Price $354.51
Cell Signaling Akap11 (E9e6w) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-77313S
MFG.PART: 77313S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 210 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | AKAP11 (E9E6W) Rabbit mAb recognizes endogenous levels of total AKAP11 protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1125 of mouse AKAP11 protein. This antigen is conserved in human. |
| Background | AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha-helix which is responsible for recruiting the PKA regulatory subunit (RIα, RIIα, RIβ, or RIIβ), individual AKAPs contain additional domains responsible for the recruitment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinases, etc.) or restricting the AKAP to a specific subcellular location (1). AKAP11 (also known as AKAP220) was originally identified in testis where it targets PKA to peroxisomes (2). Studies have also found that AKAP11 functions as an autophagy receptor targeting the R1α inhibitory subunit of PKA for degradation through a selective autophagy pathway, leading to an increase in PKA activity during nutrient deprivation (3). Exome sequencing in bipolar disorder patients identified AKAP11 as a risk gene shared with schizophrenia (4).t |
| SKU | CSIG-77313S |
|---|---|
| Supplier Part Number | 77313S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |