Cell Signaling Cd8alpha (D8a8y) Rabbit mAb (Alexa Fluor ® 555 Conjugate)

Name: Cell Signaling Cd8alpha (D8a8y) Rabbit mAb (Alexa Fluor ® 555 Conjugate)
SKU: CSIG-77909S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Cd8alpha (D8a8y) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-77909S

MFG.PART: 77909S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CD8α (D8A8Y) Rabbit mAb (Alexa Fluor® 555 Conjugate) recognizes endogenous levels of total CD8α protein. Monkey species reactivity is Immunohistochemistry (Paraffin) only.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CD8α protein.
Background	Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

Specifications