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Cell Signaling Pilra (E6h7k) Rabbit mAb
List Price $379.76 Your Price $379.76
Cell Signaling Pilra (E6h7k) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-79482S
MFG.PART: 79482S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Frozen): 1:1600 - 1:3200, Immunofluorescence (Immunocytochemistry): 1:1600 - 1:6400, Flow Cytometry (Fixed/Permeabilized): 1:400 - 1:1600, Flow Cytometry (Live): 1:400 - 1:1600} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | PILRA (E6H7K) Rabbit mAb recognizes endogenous levels of total mouse PILRA protein. |
| Species Reactivity | Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse PILRA protein. |
| Background | Paired immunoglobulin-like type 2 receptor alpha (PILRA) is an inhibitory surface receptor expressed by myeloid cells and other tissues, including microglia in the central nervous system, regulating immune cells and inflammation (1). It functions by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2, blocking downstream signal transduction via their SH2 domains (2). Furthermore, PILRA plays a role as an entry co-receptor for herpes simplex virus-1 via binding of viral glycoprotein B1 (3). More recently, mutations in the PILRA gene have been implicated in Alzheimer’s disease (AD) (1,4). Recent large-scale GWAS have linked the risk of developing late-onset AD in humans harboring rare variants of microglial immunoreceptors such as TREM2, CD33, and PILRA (5). |
| SKU | CSIG-79482S |
|---|---|
| Supplier Part Number | 79482S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |