Cell Signaling Cd11b/Itgam (D6x1n) Rabbit mAb (Alexa Fluor ® 647 Conjugate)

Name: Cell Signaling Cd11b/Itgam (D6x1n) Rabbit mAb (Alexa Fluor ® 647 Conjugate)
SKU: CSIG-79750S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Cd11b/Itgam (D6x1n) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-79750S

MFG.PART: 79750S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CD11b/ITGAM (D6X1N) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total CD11b/ITGAM protein. Monkey cross-reactivity is determined by immunohistochemistry.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD11b/ITGAM protein
Background	Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the bloodstream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematosus (SLE) (4).

Specifications