Cell Signaling Mt-Nd3 (E8o4e) Rabbit mAb

Name: Cell Signaling Mt-Nd3 (E8o4e) Rabbit mAb
SKU: CSIG-82933S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Mt-Nd3 (E8o4e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-82933S

MFG.PART: 82933S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	13
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MT-ND3 (E8O4E) Rabbit mAb recognizes endogenous levels of total MT-ND3 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ND3 protein.
Background	Mitochondrially encoded NADH dehydrogenase 3 (MT-ND3) is encoded by the mitochondrial gene MT-ND3 and is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Located in the mitochondrial inner membrane, Complex I is the largest of the five respiratory complexes and catalyzes electron transfer from NADH to ubiquinone. The mitochondrially encoded subunits of Complex I, including MT-ND3, are the most hydrophobic subunits and form the core of the transmembrane region (1,2). Pathogenic variants of the MT-ND3 gene are known to cause mitochondrial complex I deficiency (MT-C1D) and may lead to a wide range of clinical disorders, including Leigh syndrome, Leber hereditary optic neuropathy, and encephalopathy (3-5).