Cell Signaling Factor Xiiia (E980.1) Mouse mAb

Name: Cell Signaling Factor Xiiia (E980.1) Mouse mAb
SKU: CSIG-84321S
Price: 353.50 USD

List Price $353.50 Your Price $353.50

Cell Signaling Factor Xiiia (E980.1) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-84321S

MFG.PART: 84321S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{IHC Leica Bond: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	Factor XIIIA (E980.1) Mouse mAb recognizes endogenous levels of Factor XIIIA protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to a portion of the C-terminus of the blood coagulation factor XIIIa protein.
Background	Factor XIIIA, or fibrin stabilizing factor, is activated by thrombin and Ca2+ to a protransglutaminase in the final step of the blood coagulation cascade that cross-links fibrin chains (1). This enzyme catalyzes the gamma-glutamyl-epsilon-lysine cross-linking between fibrin molecules, stabilizing the fibrin clot (1,2). It is widely expressed in dermal dendritic cells (3). High expression of Factor XIIIA positive cells can be indicative of inflammatory conditions such as lichen planus and psoriasis (4).

Specifications