Cell Signaling Beta-Catenin (D10a8) Xp® Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Beta-Catenin (D10a8) Xp® Rabbit mAb (BSA And Azide Free)
SKU: CSIG-84441SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Beta-Catenin (D10a8) Xp® Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-84441SF

MFG.PART: 84441SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	92
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #8480.
Specificity/Sensitivity	β-Catenin (D10A8) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total β-catenin protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro714 of human β-catenin protein.
Background	β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

Specifications