Cell Signaling Cdx2 (D11d10) Rabbit mAb (Alexa Fluor 555 Conjugate)

Name: Cell Signaling Cdx2 (D11d10) Rabbit mAb (Alexa Fluor 555 Conjugate)
SKU: CSIG-84638S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Cdx2 (D11d10) Rabbit mAb (Alexa Fluor 555 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-84638S

MFG.PART: 84638S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CDX2 (D11D10) Rabbit mAb (Alexa Fluor® 555 Conjugate) recognizes endogenous levels of total CDX2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDX2 protein.
Background	CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development (1). CDX2 is also involved in intestinal development (2), and gain of expression or loss of expression has been associated with various human malignancies, such as Barretts esophagus (3) and colorectal cancer (4,5). Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered Hox gene expression (6), pointing to a role for CDX2 in Hox gene regulation. CDX2 is also implicated in the aberrant expression of Hox genes in human AML cell lines (7).

Specifications