Cell Signaling Plp1 Antibody

Name: Cell Signaling Plp1 Antibody
SKU: CSIG-85971S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Plp1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-85971S

MFG.PART: 85971S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	20-30
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody
Specificity/Sensitivity	PLP1 Antibody recognizes endogenous levels of total PLP1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PLP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth (1). DM20 is the result of the alternative splicing of the plp1 gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1/DM20 is linked to Pelizaeus-Merzbacher disease (2,3), including mitochondrial damage (4). In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells (5).

Specifications