Cell Signaling Tuft1 (E9m2u) Rabbit mAb

Name: Cell Signaling Tuft1 (E9m2u) Rabbit mAb
SKU: CSIG-86460S
Price: 379.76 USD

List Price $379.76 Your Price $379.76

Cell Signaling Tuft1 (E9m2u) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-86460S

MFG.PART: 86460S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	48
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TUFT1 (E9M2U) Rabbit mAb recognizes endogenous levels of total TUFT1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of murine TUFT1 protein.
Background	TUFT1 (Tuftelin 1) is a secreted protein that is primarily expressed in the dental pulp and ameloblasts, the cells responsible for producing and secreting enamel matrix proteins during tooth development. The protein is involved in the formation of enamel crystals and plays a critical role both in tooth development and maintenance (1). Some studies have suggested that TUFT1 may play a potential role in disease. TUFT1 was shown to promote metastasis in pancreatic cancer by promoting EMT (2,3), and unregulated TUFT1 expression was shown to be associated with metastatic potential and a poor prognosis in breast cancer (4). TUFT1 has also been reported to play pro-tumorigenic roles in cancer types such as renal and gastric cancer (5,6).