Cell Signaling Glucose-6-Phosphate Dehydrogenase Antibody

Name: Cell Signaling Glucose-6-Phosphate Dehydrogenase Antibody
SKU: CSIG-8866S
Price: 317.14 USD

List Price $317.14 Your Price $317.14

Cell Signaling Glucose-6-Phosphate Dehydrogenase Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-8866S

MFG.PART: 8866S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	58
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Glucose-6-Phosphate Dehydrogenase Antibody recognizes endogenous levels of total glucose-6-phosphate dehydrogenase protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human glucose-6-phosphate dehydrogenase protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first, and rate-limiting, step of the pentose phosphate pathway (1). The NADPH generated from this reaction is essential to protect cells from oxidative stress (1). Research studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway (2). In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation (2).

Specifications