Cell Signaling Cxcr4 (D4z7w) Rabbit mAb (Ihc Specific) (BSA And Azide Free)

Name: Cell Signaling Cxcr4 (D4z7w) Rabbit mAb (Ihc Specific) (BSA And Azide Free)
SKU: CSIG-90927SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cxcr4 (D4z7w) Rabbit mAb (Ihc Specific) (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-90927SF

MFG.PART: 90927SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #97680.
Specificity/Sensitivity	CXCR4 (D4Z7W) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CXCR4 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domains of human CXCR4 protein.
Background	CXCR4 is a chemokine receptor that belongs to the g protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF-1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied, as a potential therapeutic target, in the context of autoimmune diseases (3) as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4).