Cell Signaling Prostate Specific Membrane Antigen (D7i8e) Xp ® Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Prostate Specific Membrane Antigen (D7i8e) Xp ® Rabbit mAb (BSA And Azide Free)
SKU: CSIG-92728SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Prostate Specific Membrane Antigen (D7i8e) Xp ® Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-92728SF

MFG.PART: 92728SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #12815
Specificity/Sensitivity	Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total prostate specific membrane antigen. An SDS resistant dimer at approximately 200 kDa can be detected depending on sample preparation conditions.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the extracellular domain of human prostate specific membrane antigen protein.
Background	Prostate specific membrane antigen (PSMA, also known as FOLH1), a type II transmembrane protein of the M28 family, has both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase activity. PSMA was originally identified in the LNCaP cell line, which was derived from a prostate adenocarcinoma lymph node metastasis (1,2). PSMA is an established prostate cancer marker (3); however, it is expressed in other tissues, including kidney, liver, and urinary bladder (4), and it is associated with tumor neovasculature (5) as well. Research studies suggest that PSMA is both a potential diagnostic readout and therapeutic target (6-8).