Cell Signaling Tnfrsf13c/Baff-R Antibody

Name: Cell Signaling Tnfrsf13c/Baff-R Antibody
SKU: CSIG-92948S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Tnfrsf13c/Baff-R Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-92948S

MFG.PART: 92948S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	38, 50
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TNFRSF13C/BAFF-R Antibody recognizes endogenous levels of total TNFRSF13C/BAFF-R protein. This antibody also cross-reacts with an unidentified protein of 19 kDa in some cell extracts.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TNFRSF13C/BAFF-R protein. Antibodies are purified by peptide affinity chromatography.
Background	B cell-activating factor (BAFF)-receptor (BAFF-R) is a type III transmembrane protein that is expressed almost exclusively on the surface of normal, mature B cells as well as malignant B cells from various forms of B cell lymphoproliferative disorders (1). Unlike BCMA and TACI, BAFF-R only binds BAFF and this interaction plays a fundamental role in driving B cell survival and proliferation by engaging canonical and non-canonical NF-κB signaling modules (2-4). Because its expression is largely restricted to the B cell lineage, BAFF-R is being investigated as an additional immunotherapeutic target for B cell malignancies (5,6).

Specifications