Cell Signaling Tmem106b (E7h7z) Rabbit mAb

Name: Cell Signaling Tmem106b (E7h7z) Rabbit mAb
SKU: CSIG-93334S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Tmem106b (E7h7z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-93334S

MFG.PART: 93334S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	42
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:50 - 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TMEM106B (E7H7Z) Rabbit mAb recognizes endogenous levels of total TMEM106B protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala17 of human TMEM106B protein.
Background	Transmembrane protein 106B (TMEM106B) is a type II transmembrane protein with unknown function (1). TMEM106B was first identified as a major risk factor in genome-wide association studies in patients with frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder characterized by atrophy in the frontal and temporal lobes of the brain (2). Localization of TMEM106B in late endosomal and lysosomal compartments suggests a role in regulating endo/lysosomal morphology and function (3). Endo/lysosomal dysfunction is likely a major cellular pathway that contributes to FTLD as other genetically-linked FTLD genes, including C9orf72, GRN, and MAPT, converge on this cellular pathway (4).

Specifications