Cell Signaling Cd8beta (D7c8h) Rabbit mAb

Name: Cell Signaling Cd8beta (D7c8h) Rabbit mAb
SKU: CSIG-94127S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Cd8beta (D7c8h) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-94127S

MFG.PART: 94127S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	27-32
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD8β (D7C8H) Rabbit mAb recognizes endogenous levels of total CD8β protein. This antibody detects an 11 kDa band of unknown origin in some cell lines.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with mouse CD8β recombinant protein.
Background	Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).