Cell Signaling Cd7 (Lp15) Mouse mAb

Name: Cell Signaling Cd7 (Lp15) Mouse mAb
SKU: CSIG-94135S
Price: 398.95 USD

List Price $398.95 Your Price $398.95

Cell Signaling Cd7 (Lp15) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-94135S

MFG.PART: 94135S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2b
Application/Dilution	{IHC Leica Bond: 1:100 - 1:400, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD7 (LP15) Mouse mAb recognizes endogenous levels of CD7 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain of human CD7 protein.
Background	CD7 is a type-I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD7 is one of the earliest surface markers to be expressed on the surface of developing T cells and its expression is maintained throughout maturation of multiple T cell subsets and NK cells (1-3). Engagement of CD7 through binding its ligand, SECTM1, has been shown to promote tyrosine phosphorylation of its cytoplasmic domain, recruitment of PI3K, and delivery of costimulatory signals for T cell activation (4-6). While CD7 is expressed on normal T cells, it is also highly expressed in a variety of T cell malignancies, which has poised it as a potential target of immunotherapy (7-9).

Specifications