Cell Signaling Phospho-Tau (Ser396) (Phf13) Mouse mAb

Name: Cell Signaling Phospho-Tau (Ser396) (Phf13) Mouse mAb
SKU: CSIG-9632S
Price: 415.11 USD

List Price $415.11 Your Price $415.11

Cell Signaling Phospho-Tau (Ser396) (Phf13) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-9632S

MFG.PART: 9632S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	50-80
Source/Isotype	Mouse IgG2b
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-Tau (Ser396) (PHF13) Mouse mAb detects endogenous levels of Tau only when phosphorylated at serine 396.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with human purified Tau (Hoffmann et Al., 1997).
Background	Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, glycogen synthase kinase-3 (GSK-3), and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease (AD); these tangles are bundles of paired helical filaments (PHFs) composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).

Specifications