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Cell Signaling Phospho-Axl (Tyr779) Antibody
List Price
$360.57
Your Price
$360.57
Cell Signaling Phospho-Axl (Tyr779) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-96453S
MFG.PART:
96453S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 138 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Phospho-Axl (Tyr779) Antibody recognizes endogenous levels of Axl protein only when phosphorylated at Tyr779. The antibody might cross-react with other overexpressed phospho-tyrosine proteins. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phospho-peptide corresponding to residues surrounding Tyr779 of human Axl protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4).Phosphorylation of Axl receptor on Tyr779 is an indication of the receptor activation. The phosphorylation correlates to tumor progression and epithelial-mesenchymal transition (EMT), as well as drug therapy resistance (5-7). |
| SKU | CSIG-96453S |
|---|---|
| Featured | No |
| Supplier Part Number | 96453S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |