Cell Signaling Phospho-Glycogen Synthase (Ser641) (D4h1b) Xp® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Phospho-Glycogen Synthase (Ser641) (D4h1b) Xp® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-98074SF
Price: 884.76 USD

List Price $884.76 Your Price $884.76

Cell Signaling Phospho-Glycogen Synthase (Ser641) (D4h1b) Xp® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-98074SF

MFG.PART: 98074SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	85-90
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #47043
Specificity/Sensitivity	Phospho-Glycogen Synthase (Ser641) (D4H1B) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of both muscle and liver isoforms of glycogen synthase protein only when phosphorylated at Ser641.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to the sequence surrounding Ser641 of human liver glycogen synthase.
Background	Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver (1). Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals: muscle isoform (glycogen synthase 1, GYS1) and liver isoform (glycogen synthase 2, GYS2), respectively (1). Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649, and Ser653), inhibiting its activity (2,3). Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth (1).

Specifications