Cell Signaling Cr2/Cd21 Antibody

Name: Cell Signaling Cr2/Cd21 Antibody
SKU: CSIG-98245S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Cr2/Cd21 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-98245S

MFG.PART: 98245S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	150
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD21/CR2 Antibody recognizes endogenous levels of total CD21/CR2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp430 of human CD21/CR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Complement receptor type 2 (CD21/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9).

Specifications