Cell Signaling Commd3 (E2x1v) Rabbit mAb

Name: Cell Signaling Commd3 (E2x1v) Rabbit mAb
SKU: CSIG-98494S
Price: 374.71 USD

List Price $374.71 Your Price $374.71

Cell Signaling Commd3 (E2x1v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-98494S

MFG.PART: 98494S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	21
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	COMMD3 (E2X1V) Rabbit mAb recognizes endogenous levels of total COMMD3 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys187 of human COMMD3 protein.
Background	The COMMD/CCDC93/CCDC22 (CCC) protein complex contains any one of ten COMMD proteins. The CCC complex, which is a subcomplex of the commander complex, plays a key role in protecting the stability and promoting endosomal recycling of cell surface transmembrane proteins (1-3). Indeed, research studies have demonstrated that COMMD3 regulates endosomal trafficking of HER2 (4). In line with its roll in modulating endosomal trafficking of proteins, multiple functional genetic screens identified COMMD3 as a SARS-CoV-2 proviral host factor (5,6).

Specifications