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Millipore Anti-Pten Antibody, Clone 6h2.1 Detects Level Of Pten & Has Been Published & Validated For Use In Wb, Ip, Ih(P). - Mill (Additional S&H or Hazmat Fees May Apply)
The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
Product Information
Format
Purified
Presentation
Purified mouse IgG in storage buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4, with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-PTEN Antibody, clone 6H2.1 detects level of PTEN & has been published & validated for use in WB, IP, IH(P).
Key Applications
Western Blotting
Immunoprecipitation
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
C-terminal 100 amino acids of PTEN
Epitope
C-terminal region
Clone
6H2.1
Host
Mouse
Specificity
recognizes PTEN
Isotype
IgG
Species Reactivity
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_000305.3
Gene Symbol
PTEN
MMAC1
TEP1
Purification Method
Protein G Purified
UniProt Number
P60484
O08586
Molecular Weight
55 kDa
Product Usage Statements
Quality Assurance
routinely evaluated on HeLa cell lysate
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
