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Millipore This Anti-Phospho-Kdr/Flk-1/Vegfr2 (Tyr1054) Antibody, Clone D1w Is Validated For Use In Wb For The Detection Of Phospho-Kdr/Flk-1/Vegfr2 (Tyr1054). - Mill (Additional S&H or Hazmat Fees May Apply)
This Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W is validated for use in WB for the detection of phospho-KDR/Flk-1/VEGFR2 (Tyr1054).
Key Applications
Western Blotting
Application Notes
Western Blot: 1:1000-1:4000 dilution for the detection of phospho-KDR/Flk-1/VEGFR2 in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
Biological Information
Immunogen
KLH-conjugated, synthetic peptide encompassing the phosphorylated tyrosine residue 1054 of human KDR/Flk-1/VEGFR2.
Clone
D1W
Host
Rabbit
Specificity
KDR/Flk-1/VEGFR2 phosphorylated on Tyrosine 1054.
Isotype
IgG
Species Reactivity
Human
Mouse
Species Reactivity Note
Predicted to have broad species cross-reactivity based on sequence homology.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002244.1
Gene Symbol
KDR
VEGFR-2
VEGFR2
VEGFR
CD309
FLK1
Modifications
Phosphorylation
UniProt Number
P35968
UniProt Summary
FUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. SIZE: 1356 amino acids; 151527 Da SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight
152 kDa.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
