The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Anti-Aif (Apoptosis Inducing Factor) Antibody Detects Level Of Aif (Apoptosis Inducing Factor) & Has Been Published & Validated For Use In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality Level
MQ100
Applications
Application
Anti-AIF (Apoptosis Inducing Factor) Antibody detects level of AIF (Apoptosis Inducing Factor) & has been published & validated for use in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
peptide corresponding to amino acids 593-606 of human Apoptosis Inducing Factor, AIF (C-KDGEQHEDLNEVAK), containing a N-terminal cysteine
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Specificity
AIF
Isotype
IgG
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_004208
Entrez Gene Summary
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
Gene Symbol
AIFM1
MGC111425
PDCD8
AIF
Purification Method
Protein A chromatography
UniProt Number
O95831
UniProt Summary
FUNCTION: SwissProt: O95831 # Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). COFACTOR: FAD. SIZE: 613 amino acids; 66901 Da SUBUNIT: Binds to DNA in a sequence-independent manner. SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus upon induction of apoptosis. SIMILARITY: SwissProt: O95831 ## Belongs to the FAD-dependent oxidoreductase family.
Molecular Weight
57kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on a mouse liver preparation
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
