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Purified antibody in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide with 30% Glycerol.
Quality Level
MQ100
Applications
Application
Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.
Key Applications
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
peptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine
Concentration
Please refer to lot specific datasheet.
Host
Rabbit
Specificity
p70 S6 kinase
Isotype
IgG
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_003161
Entrez Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
RPS6KB1
p70-alpha
p70S6k
p70-S6K
p70
S6K
S6Kalpha)
P70S6K
STK14A
S6K1
p70(S6K)-alpha
PS6K
Purification Method
Protein A Purfied
UniProt Number
P23443
UniProt Summary
FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. SIZE: 525 amino acids; 59140 Da SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). TISSUE SPECIFICITY: Widely expressed. SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight
64 kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
