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| Description | |
|---|---|
| Catalogue Number | 07-402-25UG |
| Brand Family | Upstate |
| Trade Name |
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| Description | Anti-p70 S6 Kinase |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Purified antibody in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide with 30% Glycerol. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB. |
| Key Applications |
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| Biological Information | |
|---|---|
| Immunogen | peptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Specificity | p70 S6 kinase |
| Isotype | IgG |
| Species Reactivity |
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| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. |
| Gene Symbol |
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| Purification Method | Protein A Purfied |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. SIZE: 525 amino acids; 59140 Da SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). TISSUE SPECIFICITY: Widely expressed. SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. |
| Molecular Weight | 64 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 25 μg |