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Millipore This Anti-Trimethyl Histone H3 (Lys27) Antibody Is Validated For Use In Icc For The Detection Of Trimethyl Histone H3 (Lys27). - Mill (Additional S&H or Hazmat Fees May Apply)
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the beads on a string structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-449.
Product Information
Format
AlexaFluor®647
Presentation
Purified rabbit conjugate antibody in buffer containing PBS and 15 mg/mL BSA with 0.1% Sodium Azide.
Quality Level
MQ100
Applications
Application
This Anti-trimethyl Histone H3 (Lys27) antibody is validated for use in ICC for the detection of trimethyl Histone H3 (Lys27).
Key Applications
Immunocytochemistry
Biological Information
Immunogen
Linear peptide corresponding to Histone H3 trimethylated at Lys27.
Concentration
0.5 mg/mL
Host
Rabbit
Species Reactivity
Human
Species Reactivity Note
Human. Predicted to react with Mouse based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_003493
Gene Symbol
HIST3H3
H3FT
Purification Method
Protein A Purfied
UniProt Number
Q16695
Molecular Weight
~17 kDa observed (Refer to Cat. No. 07-449)
Product Usage Statements
Quality Assurance
Evaluated by Immunocytochemistry Analysis: in HeLa cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys27) in HeLa cells.
Alexa Fluor® is a registered trademark of Life Technologies®.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
