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Millipore Anti-Il-34 Antibody Detects Level Of Il-34 & Has Been Published & Validated For Use In Il-34. - Mill (Additional S&H or Hazmat Fees May Apply)
Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-IL-34 Antibody detects level of IL-34 & has been published & validated for use in IL-34.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the N-terminus of human IL-34.
Epitope
N-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
IL34
C16orf77
Purification Method
Antigen Affinity Purified
UniProt Number
Q6ZMJ4
Molecular Weight
~47 kDa observed. Despite its predicted molecular weight of 27 kDa, IL-34 will often run at higher molecular weight in SDS-PAGE.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human brain tissue lysate with and without blocking peptide.
Western Blotting Analysis: 0.25 μg/mL of this antibody detected IL-34 in human brain tissue lysate with and without blocking peptide.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
