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| Description | |
|---|---|
| Catalogue Number | ABN14-25UG |
| Description | Anti-Brain lipid binding protein (rabbit polyclonal) |
| Alternate Names |
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| Background Information | BLBP (Brain lipid-binding protein) belongs to a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. BLBPs play essential roles in fatty acid uptake, transport and metabolism. BLBP can be used as a molecular marker for radial glia (a major neural progenitor cell type and a scaffolding supporting neuronal migration) in the developing central nervous system. Radial glia play an essential role in the generation of the cerebral cortex through their function as neuronal precursors and as neuronal migration guides. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
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| Presentation | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect Brain lipid binding protein using this Anti-Brain lipid binding protein Antibody validated for use in WB, IH. |
| Key Applications |
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| Application Notes | Immunohistochemistry Analysis: A 1:300 dilution of ABN14 antibody from a previous lot detected Brain lipid binding protein in mouse cerebellum tissue. |
| Biological Information | |
|---|---|
| Immunogen | GST-tagged recombinant protein corresponding to human Brain lipid-binding protein. |
| Epitope | Cytoplasmic Domain |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Specificity | This antibody recognizes Brain lipid-binding protein. |
| Species Reactivity |
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| Species Reactivity Note | Proven to react with mouse. Predicted to react with human based on 100% sequence homology. Rat homology - 88%. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq]. |
| Gene Symbol |
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| Purification Method | Affinity Purfied |
| UniProt Number |
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| UniProt Summary | FUNCTION: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers By similarity. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in brain and other neural tissues. DOMAIN: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| Molecular Weight | ~ 15 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in P1 mouse brain tissue lysate. Western Blot Analysis: 0.01 µg/ml of this antibody detected Brain lipid-binding protein in 10 µg of P1 mouse brain tissue lysate. |
| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
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| Material Size | 25 μg |