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Millipore Anti-Lrrtm2 Antibody Detects Level Of Lrrtm2 & Has Been Published & Validated For Use In Lrrtm2. - Mill (Additional S&H or Hazmat Fees May Apply)
Leucine-rich repeat transmembrane neuronal protein 2
Leucine-rich repeat neuronal 2 protein
LRRTM2
Background Information
Leucine-rich repeat transmembrane neuronal protein 2, also known as Leucine-rich repeat neuronal 2 protein, and encoded by the gene name LRRTM2 or LRRN2, is involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-LRRTM2 Antibody detects level of LRRTM2 & has been published & validated for use in LRRTM2.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LRRTM2 in human brain tissue.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the cytoplasmic domain of human LRRTM2.
Epitope
cytoplasmic domain
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
LRRTM2
KIAA0416
LRRN2
Purification Method
Antigen Affinity Purified
UniProt Number
O43300
Molecular Weight
~65 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in SK-N-SH cell lysate with and without blocking peptide.
Western Blotting Analysis: 1 μg/mL of this antibody detected LRRTM2 in SK-N-SH cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
