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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R, H, M | WB, IHC | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB10422 |
| Description | Anti-Plexin-A3 Antibody, clone 18A9.2 |
| Alternate Names |
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| Background Information | Plexin-A3 is a cell surface receptor for semaphorin that controls signaling for neuronal axon regulation. Plexin-A3 is thought to play a role in Sema3F and Sema3A signaling, has been described as essential for dorsal turning of the corticospinal tract axons and may be an important contributor to development of hippocampal axonal projections. Plexin-A3 has been found expressed in newly-differentiated sympathetic neurons, but not their neural crest precursors, and together with Plexin-A4, functions cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons. |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Plexin-A3 Antibody, clone 18A9.2 is a Mouse Monoclonal Antibody for detection of Plexin-A3 also known as PLEXIN-A3, Semaphorin receptor SEX or Plexin-4 & has been validated in WB & IHC. |
| Key Applications |
|
| Application Notes | Western Blot Analysis: 1 µg/mL from a previous lot detected Plexin-A3 on 10 µg of HT-29 and NIH/3T3 cell lysates. Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Plexin-A3 in colorectal carcinoma tissue. |
| Biological Information | |
|---|---|
| Immunogen | GST-tagged recombinant protein corresponding to human Plexin-A3. |
| Clone | 18A9.2 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Isotype | IgG1κ |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq]. |
| Gene Symbol |
|
| Purification Method | Protein g |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Putative receptor involved in the development of neural and epithelial tissues. SUBCELLUALR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICTY: Predominant in neural tissue during development (By similarity); widely expressed in adult tissue. SEQUENCE SIMILARITIES: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. |
| Molecular Weight | ~220 kDa observed. The calculated molecular weight of this protein is 208 kDa; however, a higher band may be observed due to glycosolation. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in PC-12 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected Plexin-A3 on 10 µg of PC-12 cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |