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Millipore Anti-Sox-2 Antibody Detects Level Of Sox-2 & Has Been Published & Validated For Use In Ic, Ih & Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
Product Information
Format
Purified
Presentation
Purified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
Key Applications
Immunocytochemistry
Immunohistochemistry
Western Blotting
Biological Information
Immunogen
Recombinant GST Fusion protein.
Clone
6F1.2
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2b
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_003106.2
Entrez Gene Summary
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Gene Symbol
SOX2
ANOP3
MGC2413
MCOPS3
UniProt Number
P48431
UniProt Summary
FUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity). SIZE: 317 amino acids; 34310 Da SUBCELLULAR LOCATION: Nucleus. DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations. SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.
Stem Cell Type
Human Embryonic Stem Cells
Mouse Embryonic Stem Cells
Neural Stem Cells
Induced Pluripotent Stem Cells
Molecular Weight
~34 kDa
Product Usage Statements
Quality Assurance
Tested
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
