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Millipore This Anti-Taok1 Antibody (Long Isoform), Clone Tao1_1.2_Vmd Is Validated For Use In Western Blotting For The Detection Of Taok1 (Long Isoform). - Mill (Additional S&H or Hazmat Fees May Apply)
TAOK1 , also known as Serine/threonine-protein kinase TAO1, Kinase from chicken homolog B, hKFC-B, MARK Kinase, MARKK, Prostate-derived sterile 20-like kinase 2, PSK-2/PSK2, Prostate-derived STE20-like kinase 2, or Thousand and one amino acid protein kinase 1, TAOK1/hTAOK1, and encoded by the gene TAOK1/KIAA1361/MAP3K16/MARKK, is an important serine/threonine protein kinase involved in a variety of processes including p38/MAPK14 stress responses, DNA damage responses and cytoskeleton stability. TAOK1 also acts as regulator of apoptosis and controls the morphological changes associated with apoptosis including cell contraction, membrane blebbing and apoptotic body formation. TAOK1 is expressed in many tissues but highly expressed in testis as well as brain, colon and muscle. TAOK1 is localized to the cytoplasm and a target for caspase-3 as well as SPRED1 a regulator of the MAP kinase cascade.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-TAOK1 Antibody (long isoform), clone TAO1_1.2_VMD is validated for use in Western Blotting for the detection of TAOK1 (long isoform).
Key Applications
Western Blotting
Application Notes
Western Blotting Analysis: A representative lot detected TAOK1 in HeLa cell lysate, but not in TAOK1 siRNA transfected HeLa cell lysate (Prof. Viji Draviam, University of Cambridge).
Biological Information
Immunogen
Linear peptide corresponding to the C-terminus of human TAOK1.
Epitope
C-terminus
Clone
1.2
Concentration
1 mg/mL
Host
Mouse
Isotype
IgG2bκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_065842
Gene Symbol
TAOK1
KIAA1361
MAP3K16
MARKK
Purification Method
Protein g Purified
UniProt Number
Q7L7X3
Molecular Weight
~116 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected TAOK1 in 10 µg of HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
