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Millipore This Anti-Phospho-Ulk1 (Ser 467) Antibody, Clone 15d12.3 Is Validated For Use In Western Blotting For The Detection Of Phospho-Ulk1 (Ser 467). - Mill (Additional S&H or Hazmat Fees May Apply)
ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. ULK1 may play an important role in neuronal development: Elimination of ULK1s enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgMλ supernatant in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-phospho-ULK1 (Ser 467) antibody, clone 15D12.3 is validated for use in western blotting for the detection of phospho-ULK1 (Ser 467).
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human phospho-ULK1 (Ser 467).
Clone
15D12.3
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgMλ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_003556
Gene Symbol
ULK1
KIAA0722
Purification Method
Protein G Purified
UniProt Number
O75385
Molecular Weight
~112 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in A-431 serum starved cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected phospho-ULK1 (Ser467) in 10 µg of A-431 serum starved cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
