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Millipore Anti-Bmr2 Antibody, Clone 3f6 Is A Mouse Monoclonal Antibody, Validated For Use In Western Blotting, Immunofluorescence & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Bone morphogenetic protein receptor type-2BMP type-2 receptor
BMPR-2
Bone morphogenetic protein receptor type II
BMP type II receptor
BMPR-II
Background Information
BMPR2 a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-β superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Product Information
Format
Ascites
Control
HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates
Presentation
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-BMR2 Antibody, clone 3F6 is a mouse monoclonal antibody, validated for use in western blotting, Immunofluorescence & IHC.
Key Applications
Western Blotting
Immunofluorescence
Immunohistochemistry
Application Notes
Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected BMPR2 in Eca109 cells.
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected BMPR2 in muscle tissue and kidney cancer tissue.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen
Purified recombinant fragment of human BMR2 expressed in E. Coli.
Clone
3F6
Host
Mouse
Isotype
IgG1
Species Reactivity
Human
Mouse
Rat
Monkey
Antibody Type
Monoclonal Antibody
Gene Symbol
BMR2
PPH1
BMPR3
BRK-3
T-ALK
BMPR-II
FLJ41585
FLJ76945
BMPR2
Purification Method
Unpurified
Molecular Weight
~115 kDa observed. Uncharacterized bands may appear in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates.
Western Blot Analysis: A 1:500-2,000 dilution of this antibody detected BMPR2 in HeLa, A431, NIH/3T3, Cos7 and PC-12 cell lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
