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Millipore Anti-Fox1 Antibody, Clone D8f8 Is A Mouse Monoclonal Antibody For Detection Of Fox1 Also Known As Hexaribonucleotide Binding Protein 1, Ataxin-2-Binding Protein 1 & Has Been Validated In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Fox1, also commonly referred to as Ataxin-2-binding protein 1, is an RNA binding protein involved in the regulation of tissue-specific alternative splicing. This protein contains a highly conserved RRM (RNA recognition motif) and associates with 5-UGCAUGU-3 elements. This protein has been demonstrated to regulate alternative splicing of tissue specific exons and differentially spliced exons during erythropoiesis. Its alternative name, Ataxin-2-binding protein, is a result of its association with the C terminus of ataxin 2 which may contribute to the pathology of the neurogenerative disease spinocerebellar ataxia type 2 (SCA2).
Product Information
Format
Purified
Control
Mouse heart tissue lysate
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Fox1 Antibody, clone D8F8 is a Mouse Monoclonal Antibody for detection of Fox1 also known as hexaribonucleotide binding protein 1, Ataxin-2-binding protein 1 & has been validated in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
Recombinant protein corresponding to mouse Fox1.
Clone
D8F8
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_067452
Gene Symbol
FOX1
A2BP1
A2BP
Purification Method
Protein G
UniProt Number
Q9JJ43
UniProt Summary
FUNCTION: RNA-binding protein that regulates alternative splicing events by binding to 5-UGCAUGU-3 elements. Prevents binding of U2AF2 to the 3-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
SUBUNIT STRUCTURE: Binds to the C-terminal of ATXN2.
~55 kDa observed. Uncharacterized bands potentially due to alternative splicing have been observed at ~33 and 37 kDa.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in mouse heart tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Fox1 on 10 µg of mouse heart tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
