The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
NETA ALERT: Due to inclement weather our offices are closed today, Monday Feb. 23. We will not be shipping orders.
Millipore This Anti-Lymphoid-Specific Helicase (Smarca6) Antibody, Clone 2g7.1 Is Validated For Use In Western Blotting & Ihc For The Detection Of Lymphoid-Specific Helicase (Smarca6). - Mill (Additional S&H or Hazmat Fees May Apply)
SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Background Information
A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5 DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1 is validated for use in western blotting & IHC for the detection of Lymphoid-specific helicase (SMARCA6).
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lymphoid-specific helicase (SMARCA6) in human placenta tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Lymphoid-specific helicase (SMARCA6).
Clone
2G7.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_060533
Gene Symbol
HELLS
PASG
SMARCA6
Purification Method
Protein G Purified
UniProt Number
Q9NRZ9
Molecular Weight
~97 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human thymus tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lymphoid-specific helicase (SMARCA6) in 10 µg of human thymus tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
