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Millipore Anti-Wdr5 Antibody, Clone 7b11 Is A Highly Specific Mouse Monoclonal Antibody & That Targets Wdr5 & Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
WD repeat-containing protein 5 (WDR5) or alternatively BMP2-induced 3kb gene protein, is encoded by the human gene named WDR5/BIG3 and is part of a family of WD-40 repeat proteins that appear to facilitate the formation of multi-protein complexes much like a sticky tape will bind a variety of components together. The WD repeat proteins are involved in a wide array of cellular functions and processes including cell cycle progression, homeobox gene activation, apoptosis, gene regulation and histone methylation. One of WDR5 best studied activities is as part of a multi-protein complex that facilitates the methylation of histones, particularly histone H3, through its interaction with MLL a histone methyltransferase. WDR5 is also expressed in developing bone cells including osteoblasts, chondrocytes, and marrow stromal cells and works to accelerate osteoblast differentiation and positively promotes Wnt signaling in developing bone tissues. EMD-Millipore’s Anti-WDR5 mouse monoclonal antibody has been tested in western blot using HeLa cell lysates.
Product Information
Format
Ascites
Control
HeLa cell lysate
Presentation
Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-WDR5 Antibody, clone 7B11 is a highly specific mouse monoclonal antibody & that targets WDR5 & has been tested in western blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
Purified recombinant fragment of human WDR5 expressed in E. Coli.
Clone
7B11
Host
Mouse
Isotype
IgG2b
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Gene Symbol
SWD3
BIG-3
WDR5
Purification Method
Unpurified
Molecular Weight
~40 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected WDR5 in HeLa cell lysate.
Optimal working dilutions must be determined by end user.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
