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Millipore This Anti-Mbnl2 Antibody, Clone Mb2a(3b4) Is Validated For Use In Western Blotting For The Detection Of Mbnl2. - Mill (Additional S&H or Hazmat Fees May Apply)
MBNL2, also known as Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, or Muscleblind-like protein-like 39, and encoded by the gene MBNL2/MBLL/MBLL39/MLP1, is a protein that mediates pre-mRNA alternative splicing regulation. MBNL2 acts either as an activator or repressor of splicing on specific pre-mRNA targets. For instance MBNL2 inhibits cardiac troponin-T pre-mRNA exon inclusion but induces insulin receptor pre-mRNA exon inclusion in muscle. MBNL2 may also regulate ITGA3 expression by transporting it from the nucleus to cytoplasm at adhesion plaques. MBNL2 appears to play a key role in the muscle disease named myotonic dystrophy pathophysiology. MBNL2 is expressed in the nucleus of cells in multiple tissues but can be found in the cytoplasm in certain situations. In particular it is found in the cytoplasm in adhesion plaques.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-MBNL2 Antibody, clone MB2a(3B4) is validated for use in Western Blotting for the detection of MBNL2.
Key Applications
Western Blotting
Biological Information
Immunogen
Recombinant protein corresponding to human MBNL2.
Clone
MB2a(3B4)
Concentration
1 mg/mL
Host
Mouse
Isotype
IgG2bκ
Species Reactivity
Mouse
Species Reactivity Note
Mouse. Predicted to react with Human based on 100% sequence homology.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_659002
Gene Symbol
MBNL2
MBLL
MBLL39
MLP1
Purification Method
Protein G Purified
UniProt Number
Q5VZF2
Molecular Weight
~40 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in C2C12 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected MBNL2 in 10 µg of C2C12 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
