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Millipore Anti-Microsialin/Cd68 Antibody, Clone 9 Is An Antibody Against Microsialin/Cd68 For Use In Flow Cytometry. - Mill (Additional S&H or Hazmat Fees May Apply)
Microsialin/CD68, also known as Macrosialin, Gp110, CD_antigen 68, or CD68, and encoded by the gene CD68, is a membrane protein expressed in macrophages (and other cells) that appears to play a role in the phagocytic activities of tissue macrophages both in intracellular lysosomal metabolism but also in extracellular cell to cell interactions and cell pathogen interactions. Microsialin binds to tissue and organ-specific lectins or selectins mediating homing of macrophage subsets to particular sites. Also, rapid recirculation of Microsialin from the endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selection-bearing substrates or other cells. Microsialin is expressed in blood monocytes and tissue macrophages primarily but is also found expressed in lymphocytes, fibroblasts and endothelial cells so it is not an exclusive marker for macrophages. Also Microsialin is expressed on many tumor cells which seem to allow the tumor cells to attach to selectins on the vascular endothelium facilitating their dissemination to secondary sites.
Product Information
Format
Purified
Presentation
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.
Key Applications
Flow Cytometry
Biological Information
Immunogen
Recombinant protein corresponding to mouse Microsialin/CD68.
Clone
9
Concentration
1 mg/mL
Host
Rat
Isotype
IgG2aκ
Species Reactivity
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_033983
Gene Symbol
Cd68
Purification Method
Protein G Purified
UniProt Number
P31996
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in RAW264.7 cells.
Flow Cytometry Analysis: 2 µg of this antibody detected Microsialin/CD68 in 1X10E6 cells.
This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
