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Millipore Anti-Il1rl1 Antibody, Clone Rmst2-2, Azide Free Is An Antibody Against Il1rl1 For Use In Flow Cytometry & Activity Assay. - Mill (Additional S&H or Hazmat Fees May Apply)
IL1RL1, or Interleukin-1 receptor-like 1 protein, which is also known as Lymphocyte antigen 84, Protein ST2, or Protein T1, and encoded by the gene IL1rL1/Ly84/St2/Ste2 is the receptor for IL-33 and its activation recruits MYD88, IRAK1, IRAK4 and TRAF6 transcription factors and promotes the activation of ERK1/MAPK14 and MAPK8. IL1RL1 also is involved in T-helper Cell activation and function. IL1RL1 is localized to the plasma membrane. IL1RL1 is expressed in hematopoietic tissues, macrophages, epithelial and fibroblast cells lines as well as important tissues such as heart and lung. IL1RL1 is a member of the Toll-like receptor superfamily and interestingly plays an important role not in inflammation but in cardiac protection. When IL-33 binds it elicits a cardioprotective signaling response in the tissue and thus helps protect the heart tissue during times of ischemia for instance. Defects in IL1RL1 have been linked to atopic dermatitis and asthma.
Product Information
Format
Purified
Presentation
PBS without preservatives
Quality Level
MQ100
Applications
Application
Anti-IL1RL1 antibody, clone RMST2-2, Azide Free is an antibody against IL1RL1 for use in flow cytometry & activity assay.
Key Applications
Flow Cytometry
Activity Assay
Application Notes
Activity Assay Analysis: A representative lot from an independent laboratory induces IL-6 production in BMCC cells (Prof. Hisaya Akiba, Jutendo University).
Biological Information
Immunogen
Mouse ST-2/IL1RL1.
Clone
RMST2-2
Host
Rat
Isotype
IgG2aκ
Species Reactivity
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001020773
Gene Symbol
Il1rl1
Ly84
St2
Ste2
Purification Method
Protein G Purified
UniProt Number
P14719
Molecular Weight
64 kDa calculated
Product Usage Statements
Quality Assurance
Evalauted by Flow Cytometry in ST2/L5178Y and L5178Y parent cells.
Flow Cytometry Analysis: 1 µg of this antibody detected IL1RL1 in 1X10E6 ST2/L5178Y cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
