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Millipore Anti-Rabies Virus, Clone 1112-1, Cat. No. Mabf949, Is A Mouse Monoclonal Antibody That Detects Glycoprotein Of Strain Era Rabbies Virus. It Has Been Tested For Use In Flow - Mill (Additional S&H or Hazmat Fees May Apply)
Glycoprotein of Evelyn Rokitniki Abelseth (ERA) SAD derived Rabies virus strain (UniProt: P03524) is encoded by the g gene. It belongs to the lyssavirus glycoprotein of the Rhabdoviridae family. This glycoprotein is a single pass type I virion membrane protein that helps in attaching the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. It has been shown that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (N-CAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and facilitate rabies virus entry into cells. Arg352 of Glycoprotein is highly involved in rabies virus pathogenicity and mutation at this site dramatically attenuates the virus.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal antibody IgG1 in PBS without azide.
Quality Level
MQ100
Applications
Application
Anti-Rabies Virus, clone 1112-1, Cat. No. MABF949, is a mouse monoclonal antibody that detects glycoprotein of strain ERA rabbies virus. It has been tested for use in Flow Cytometry and for Neutralizing.
Glycoprotein of ERA (Evelyn Rokitniki Abelseth) strain Rabies virus.
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 1112-1 detects glycoprotein of ERA strain of rabies virus in L929 cells that express rabies protein.
Isotype
IgG1
Species Reactivity
Virus
Species Reactivity Note
Rabies Virus.
Antibody Type
Monoclonal Antibody
Purification Method
Protein g purified
UniProt Number
P03524
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in L929 expressing rabies protein. Flow Cytometry Analysis: 1 µg of this antibody detected Rabies Virus in one million L929 cells expressing rabies protein.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
