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Millipore This Anti-Parvalbumin Antibody, Clone 4e9.2 Is Validated For Use In Western Blotting, Immunohistochemistry (Paraffin) For The Detection Of Parvalbumin. - Mill (Additional S&H or Hazmat Fees May Apply)
Parvalbumin alpha (UniProt P02625; also known as PV) is encoded by the Pvalb (also known as Pva) gene (Gene ID 25269) in rat species. Parvalbumin alpha is a small (a.a. 2-110; Met1 removed posttranslationally) calcium-binding protein. Parvalbumin alpha is composed almost entirely of two EF-hand domains (a.a. 39-74 & 78-110) and is structurally related to calmodulin and troponin C. Parvalbumin (PV) is present in GABAergic interneurons in the nervous system, especially the reticular thalamus. PV interneurons are a subset of inhibitory GABAergic neurons that control the excitability of post-synaptic pyramidal neurons. Dysfunction or loss of PV interneurons is implicated in cognitive deficits associated with a number of well known psychiatric disorders, including schizophrenia, Alzheimer’s disease, and depression.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1 antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Parvalbumin Antibody, clone 4E9.2 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Parvalbumin.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Parvalbumin in human kidney, rat kidney, and mouse cerebral cortex tissue sections.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of rat parvalbumin.
Epitope
Internal (N-terminal half).
Clone
4E9.2
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 4E9.2 detects an epitope conserved among human, mouse, and rat species.
Isotype
IgG1
Species Reactivity
Human
Mouse
Rat
Species Reactivity Note
Human, Mouse, Rat.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_071944
Gene Symbol
Pvalb
Pva
Purification Method
Protein G purified.
UniProt Number
P02625
Molecular Weight
~12 kDa observed. 11.93 kDa (human), 11.80 kDa (mouse), 11.79 kDa (rat) calculated (Met1 removed). Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected Parvalbumin in 10 µg of mouse brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
