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Millipore Detect Hand2 Using This Anti-Hand2 Antibody, Clone 7d4.1 Validated For Use In Western Blotting & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Heart- and neural crest derivatives-expressed protein 2
Class A basic helix-loop-helix protein 26
bHLHa26
Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
dHAND
Background Information
Heart-and neural crest derivatives-expressed protein 2 , also known as Class A basic helix-loop-helix protein 26 (bHLHa26), or Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), and encoded by the gene HAND2/BHLHA26/DHAND, is a transcription factor that is essential for cardiac morphogenesis, particularly the formation of the right ventricle and the aortic arch arteries. Heart-and neural crest derivatives-expressed protein 2 is required for vascular development, angiogenesis and for limb development acting upstream of sonic hedgehog in the induction of the limb bud. Additionally, Heart-and neural crest derivatives-expressed protein 2 is central to cardiac neural crest cell development and involved in outflow tract morphogenesis as well as the maintenance of the adult heart and in the negative regulation of cardiac muscle cell apoptosis. Heart-and neural crest derivatives-expressed protein 2 is localized to the nucleus. Heart-and neural crest derivatives-expressed protein 2 is expressed in developing heart, lung and vascular system.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HAND2 in human placenta tissue.
Biological Information
Immunogen
Recombinant protein corresponding to the C-terminus outside the bHLH domain of human HAND2.
Epitope
C-terminus outside the bHLH domain
Clone
7D4.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Mouse
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_068808
Gene Symbol
HAND2
BHLHA26
DHAND
Purification Method
Protein G Purified
UniProt Number
P61296
Molecular Weight
~30 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in mouse heart tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected HAND2 in 10 µg of mouse heart tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
